The Dynamics of Clindamycin - 2 - Phosphate in vivo and its Transfer to Tissues Takashi IMOTO , Kenji TAKASAKi , Shigeru MIYACHI

rabbits following continuous intrayenous infusion of 20rnglkg oyer a 60 minute period, and the results were compared in a cressover test. 2} The concentration of CLDM phosphate in the oral tissues of rabbits following continuous intravenous drip infusion of 20mg/kg over a 60 minute period was found to be a maximum in the submaxillary gland {21.1nglg), followed br the liver, submaxillary lymph nodes, sera and tongue. The concentration of LCM was found to be the highest in the submaxillary gland (20.2"g/g), followed bT the submaxillary lyrnph nodes, tongue, sera and liver. 3> The metabolism of CLDM phosphatc in vive was investigated using TLC. CLDM phosphate was found to metaboIize to CLDM N-demethyl CLDM in tivo. 4) The peak concentration of CLDM phosphate in human sera following intravenous drip infusion of 600mg over a 60 minute period averaged 11.9ptg/ml, while the average concentration of LCM in sera under identical circumstances was approximately twice that of CLDM phosphate.